The capacity of pharmaceutical agents to selectively find their biological targets is an important determinant of their usefulness in clinical medicine. Many pharmaceutics are directed against intracellular targets that reside in organelles. Carriers that selectively target these subcellular structures have been investigated, and include nanoparticulate drug carriers, chemically modified proteins

Medulloblastoma (MB) is a highly invasive pediatric tumor of the cerebellum. Despite a better cure rate due to multimodal treatments that associate chemotherapy, surgery and radiotherapy (RT), 20-30% of the children are incurable. Moreover, survivors suffer from important side effects. Transcriptomic analyses have defined 4 molecular subgroups of MB. Among them, the group 3 which represents 25% of

The cancer cell adhesome consists of cell adhesion molecules (CAMs), growth factor receptors (GFR), adapter and signaling proteins, which mutually and cooperatively interact. The impact of these tightly regulated CAM/GFR interactions has not been described for the interrelation between cellular radiosensitivity and cancer cell-induced angiogenesis. Using the area vasculosa model of the chicken emb

Defects of mitochondrial function have long been suspected to contribute to the development and progression of cancer. Mitochondria besides their roles as powerhouses and biosynthetic hubs are a main source of ROS. Indeed, the maintenance of the mitochondrial potential by means of electron transfer chain (ETC) during respiration produces superoxide as a main byproduct. In cancer cells, it has been

Hypoxia is a common feature of human solid tumors and is considered as one main biological factor promoting tumor cell resistance to radiotherapy. Others and we revealed that chronic intermittent hypoxia acts as an important driver of adaptive changes that allow the cancer cells to survive these highly adverse conditions and promote tumor heterogeneity. A hypoxia/reoxygenation-induced metabolic re