The National Center for Radiation Research in Oncology – OncoRay, is a public research institution founded and operated by Universitätsklinikum Carl Gustav Carus Dresden, Medizinische Fakultät Carl Gustav Carus der Technischen Universität Dresden (TUD) and the Helmholtz-Zentrum Dresden-Rossendorf. The core of OncoRay research is built around innovative proton and ionizing radiation facilities for treatment for patients and translational research in the fields of medicine, physics, and biology. The overarching aim is to achieve a technical and biological individualized cancer therapy.
The research of the Molecular and Cellular Radiobiology (MCR) group is focused on the elucidation of the cellular and molecular response to ionizing radiation aiming at the identification and targeting of new tumor-specific molecules involved in therapy resistances. The group has pioneered the field of 3D cell cultures in radiobiology and extensively characterized and validated such cultures in comparison to in-vivo growth conditions. Additionally, the group pioneered the role of integrins and focal adhesion proteins and their contribution to therapy resistance in many cancer types such as head and neck squamous cell carcinomas, glioblastoma and pancreatic cancer.a